GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs703842 | 1 | rs11172343 | chr12:58188157 | FAM119B | chr12:58166383-58176323:+ | 0.42 | 5.72 | 1.22E-7 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs11172343 | chr12:58188157 | TSFM | chr12:58176536-58191367:+ | -0.29 | -5.12 | 1.6E-6 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs11172344 | chr12:58193448 | FAM119B | chr12:58166383-58176323:+ | 0.41 | 5.83 | 7.7E-8 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs11172344 | chr12:58193448 | TSFM | chr12:58176536-58191367:+ | -0.28 | -5.16 | 1.33E-6 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs11172349 | chr12:58212528 | FAM119B | chr12:58166383-58176323:+ | 0.42 | 5.74 | 1.15E-7 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs11172349 | chr12:58212528 | TSFM | chr12:58176536-58191367:+ | -0.29 | -5.08 | 1.9E-6 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs11172351 | chr12:58213485 | FAM119B | chr12:58166383-58176323:+ | 0.42 | 5.77 | 9.91E-8 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs11172351 | chr12:58213485 | TSFM | chr12:58176536-58191367:+ | -0.29 | -5.04 | 2.21E-6 | Multiple sclerosis |
| THYM | cis | rs11191419 | 1 | rs11191419 | chr10:104612335 | AS3MT | chr10:104613967-104661653:+ | -0.47 | -6.56 | 2.86E-9 | Schizophrenia |
| THYM | cis | rs4409766 | 1 | rs11191425 | chr10:104625970 | SFXN2 | chr10:104474298-104498946:+ | -0.53 | -4.4 | 2.85E-5 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| THYM | cis | rs12220777 | 1 | rs11201312 | chr10:81795778 | LOC219347 | chr10:81805991-81838949:- | 0.65 | 4.43 | 2.48E-5 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs4660306 | 1 | rs11211132 | chr1:45990516 | CCDC163P | chr1:45960581-45965646:- | -0.85 | -14.31 | 1.95E-25 | Homocysteine levels |
| THYM | cis | rs2275426 | 1 | rs11211199 | chr1:46287869 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -5.85 | 6.8E-8 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs11211208 | chr1:46334256 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -5.85 | 6.8E-8 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs11211230 | chr1:46406767 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |